光学成像中兼具光学和力学性质的生物组织仿体

在生物医学光学成像方法的研发、评估和使用中,需要用到在较长时间内具有稳定的光学及力学属性的生物组织仿体,以使光学成像实验可以重复进行。这些仿体一般由混有散射、吸收粒子的基质制成。常用散射粒子包括脂质微粒、聚合物微球、金属氧化物粉末和金纳米粒子等,吸收粒子(及其溶液)包括血液、印度墨水(Indian Ink)和分子染料等。常用来模拟组织特性的基质包括硅胶、纤维蛋白和聚乙烯醇凝胶(Polyvinyl alcohol cryogel,PVA-C)等。讨论和分析常见仿体的光学性质(吸收系数、散射系数、折射率)和力学性质(弹性和粘弹性)。从生物相容性、制备难易程度及耗时情况、稳定性等方面比较了几种常见散射粒子、吸收粒子和基质的优缺点,并据此总结其适用范围。最后对仿体研究的发展进行了展望。

Tissue Phantoms with Optical and Mechanical Properties In O ptical Imaging

In the development,evaluation and usage of biomedical optical imaging method a biomedical tissue phantom with stable optical and mechanical parameters during a long period of time is needed,so that the optical imaging experi-ments can be repeated.Those phantoms are made by certain substance mixed with some certain scattering particles and absorbing particles.Common scattering particles include lipids,polymer,micro-spheres,metal oxides,gold nano-parti-cles etc.,while absorbing particles(and its solution)include blood,Indian ink,molecular dyes etc.The common sub-stances to simulate characteristics of tissue include silicone,fibrin and Poly(vinyl alcohol)cryogel (PVA-C)etc.The state of art durable tissue phantoms are reviewed and analyzed in optical properties involving absorbing index,scattering index and refractive index as well as medical properties involving elasticity and viscoelasticity.The advantages,disad-vantages in biocompatibility,difficulty in preparation and time consumed and durability are compared.And its scope issummarized depending on the characteristics of the tissue phantoms.At last,the development of the phantoms is dis-cussed.