Synthesis and pharmacological evaluation of prenylated and benzylated pterocarpans against snake venom |
| |
| Authors: | da Silva Alcides J M Coelho Antonio L Simas Alessandro B C Moraes Raphael A M Pinheiro Diogo A Fernandes Fabrício F A Arruda Emerson Z Costa Paulo R R Melo Paulo A |
| |
| Affiliation: | Laboratório de Química Bioorganica (LQB), Núcleo de Pesquisas de Produtos Naturais, Centro de Ciências da Saúde, Bloco H, Universidade Federal do Rio de Janeiro, RJ 21941-590, Brazil. |
| |
| Abstract: | Edunol (3), a pterocarpan isolated from Harpalyce brasiliana, a plant used in the northeast of Brazil against snakebites, was obtained by synthesis and showed antimyotoxic, antiproteolytic and PLA2 inhibitor properties. These proprieties could be improved through the synthesis of a bioisoster (5), where the prenyl group was replaced by the benzyl group. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
