Effect of thyroidectomy on fast and slow muscle fibres of rat gastrocnemius muscle |
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Authors: | Vashishta N Talesara C L |
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Institution: | Muscle Physiology & Histochemistry Unit, Department of Zoology, University of Delhi, Delhi 110007, India. |
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Abstract: | A combined histochemical, biochemical and electrophoretic study with respect to the enzymes succnic dehydrogenase(SDH), myofibrillar adenosine triphosphatase (m-ATPase), lactate dehydrogenase (LDH) isozymes and myosin light chains was carried out to investigate the response of rat gastrocnemius muscle (medial head). Twelve weeks after thyroidectomy, the results indicated a shift from fast to slow type pattern of LDH isozymes, fibre type transformation from Type II to Type I and a decrease in SDH and m-ATPase activity. The results suggest, possible thyroidal involvement in determining the phenotypic properties of skeletal muscle. |
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