Evidence of oxidative stress and mitochondrial respiratory chain dysfunction in an in vitro model of sepsis-induced kidney injury |
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| Authors: | C. Quoilin,A. Mouithys-Mickalad,S. Lé cart,M.-P. Fontaine-Aupart,M. Hoebeke |
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| Affiliation: | 1. Laboratory of Biomedical Spectroscopy, Department of Physics, University of Liège, 4000 Liège, Belgium;2. Center of Oxygen Research and Development, Department of Chemistry, University of Liège, 4000 Liège, Belgium;3. Centre de Photonique Biomédicale, CPBM/CLUPS, Fédération LUMAT, University Paris Sud, 91405 Orsay, France;4. Institut des Sciences Moléculaires d''Orsay, CNRS and University Paris Sud, 91405 Orsay, France |
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| Abstract: | ![]()
To investigate the role of oxidative stress and/or mitochondrial impairment in the occurrence of acute kidney injury (AKI) during sepsis, we developed a sepsis-induced in vitro model using proximal tubular epithelial cells exposed to a bacterial endotoxin (lipopolysaccharide, LPS). This investigation has provided key features on the relationship between oxidative stress and mitochondrial respiratory chain activity defects. |
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