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ATP-Dependent Dynamic Protein Aggregation Regulates Bacterial Dormancy Depth Critical for Antibiotic Tolerance
Authors:Yingying Pu  Yingxing Li  Xin Jin  Tian Tian  Qi Ma  Ziyi Zhao  Ssu-yuan Lin  Zhanghua Chen  Binghui Li  Guang Yao  Mark C Leake  Chien-Jung Lo  Fan Bai
Institution:1. Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University, Beijing 100871, China;2. Department of Physics and Graduate Institute of Biophysics, National Central University, Jhong-Li, Taoyuan 32001, Republic of China;3. Department of Biochemistry and Molecular Biology, Capital Medical University, Beijing, Beijing 100069, China;4. Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA;5. Department of Physics, University of York, York YO10, UK;6. Department of Biology, University of York, York YO10, UK
Abstract:
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  • Keywords:bacterial antibiotic tolerance  persisters  dormancy depth  cell resuscitation  protein aggregates  ATP  DnaK-ClpB complex  viable but non-culturable cells
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