Mulberry anthracnose antagonists (iturins) produced by Bacillus amyloliquefaciens RC-2 |
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Authors: | Hiradate Syuntaro Yoshida Shigenobu Sugie Hajime Yada Hiroshi Fujii Yoshiharu |
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Institution: | Department of Biological Safety Science, National Institute for Agro-Environmental Sciences, 3-1-3 Kan-nondai, Tsukuba, Ibaraki 305-8604, Japan. hiradate@affrc.go.jp |
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Abstract: | Bacillus amyloliquefaciens strain RC-2 produced seven antifungal compounds (1-7) secreted into the culture filtrate. These compounds inhibited the development of mulberry anthracnose caused by the fungus, Colletotrichum dematium. Chemical structural analyses by NMR and FAB-MS revealed that all these compounds were iturins (cyclic peptides with the following sequence: L-Asn --> D-Tyr --> D-Asn --> L-Gln --> L-Pro --> D-Asn --> L-Ser --> D-beta-amino acid -->) and compounds 1-6 are identical to iturins A-2-A-7, respectively. Compound 7 (iturin A-8) is a new iturin, which has a -(CH(2))(10)CH(CH(3))CH(2)CH(3) group as a side chain in the beta-amino acid in the molecule. |
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Keywords: | Bacillus amyloliquefaciens Iturin Cyclic peptide β-amino acid Colletotrichum dematium Mulberry anthracnose |
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