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A glimpse into molecular mechanisms of embryonic stem cells pluripotency: Current status and future perspective |
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| Authors: | Nazila Fathi Maroufi Kouichi Hasegawa Vahid Vahedian Saeed Nazari Soltan Ahmad Amir Zarebkohan Seyed Ali Miresmaeili Mazrakhondi Vahid Hosseini Reza Rahbarghazi |
| Institution: | 1. Stem Cell and Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran;2. Institute for Integrated Cell-Material Sciences, Institute for Advanced Study, Kyoto University, Kyoto, Japan;3. Department of Medical Laboratory Sciences, Faculty of Medicine, Islamic Azad University, Sari, Iran Clinical Laboratory Medicine Department, Rofeydeh Hospital University of Social Welfare and Rehabilitation Science, Tehran, Iran;4. Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran;5. Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran;6. Department of Biology, Faculty of Basic Sciences, Yazd University, Yazd, Iran;7. Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran |
| Abstract: | Embryonic stem cells have potential differentiation ability into a large variety of cell lineages and proved to be an effective therapeutic modality. However, prolonged in vitro and ex-vivo expansions impair embryonic stem cells multipotentiality, and thereby limit their clinical application. In the past few years, research collected attempts to explore new insights into the molecular mechanisms participate in the stemness capacity of embryonic stem cells. Along with these comments, modalities and strategies with the potential to maintain embryonic stem cells multipotentiality are of great interest. In this review, the authors attempted to discuss the pathways participating in the preservation of embryonic stem cells multipotentiality and emphasized the novel strategies that help to harness regenerative potential. |
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