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Prospects for the involvement of cancer stem cells in the pathogenesis of osteosarcoma |
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| Authors: | Sama Izadpanah Parastoo Shabani Ali Aghebati-Maleki Amir Baghbanzadeh Ali Fotouhi Amir Bisadi Leili Aghebati-Maleki Behzad Baradaran |
| Institution: | 1. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Sama Izadpanah and Parastoo Shabani contributed equally to this work.;2. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran;3. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;4. Department of Orthopedic Surgery, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran |
| Abstract: | Osteosarcoma (OS) is one of the most common bone tumors in children and adolescents that cause a high rate of mortality in this age group and tends to be metastatic, in spite of chemotherapy and surgery. The main reason for this can be returned to a small group of malignant cells called cancer stem cells (CSCs). OS-CSCs play a key role in the resistance to treatment and relapse and metastasis through self-renewal and differentiation abilities. In this review, we intend to go through the different aspects of this malignant disease, including the cancer stem cell-phenotype, methods for isolating CSCs, signaling pathways, and molecular markers in this disease, and drugs showing resistance in treatment efforts of OS. |
| Keywords: | cancer stem cell drug resistance osteosarcoma treatment |