Neuroprotective activities of bacopa,lycopene, astaxanthin, and vitamin B12 combination on oxidative stress-dependent neuronal death |
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| Authors: | Vanessa Castelli Francesco Melani Claudio Ferri Michele d'Angelo Mariano Catanesi Davide Grassi Elisabetta Benedetti Antonio Giordano Annamaria Cimini Giovambattista Desideri |
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| Institution: | 1. Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy;2. Menarini Industrie Farmaceutiche Riunite srl, Florence, Italy;3. Department of Biology, Sbarro Institute for Cancer Research and Molecular Medicine and Center for Biotechnology, Temple University, Philadelphia, Pennsylvania |
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| Abstract: | Oxidative stress is considered the common effector of the cascade of degenerative events in many neurological conditions. Thus, in this paper we tested different nutraceuticals in H2O2 in vitro model to understand if could represent an adjuvant treatment for neurological diseases. In this study, nutraceuticals bacopa, lycopene, astaxanthin, and vitamin B12 were used alone or in combination in human neuronal differentiated SH-SY5Y cells upon hydrogen peroxide-induced injury and neuroprotective, neuronal death pathways were analyzed. The nutraceuticals analyzed were able to protect H2O2 cytotoxic effects, through increasing cell viability and proteins involved in neuroprotection pathways and restoring proteins involved in cell death pathways. On this basis, it is possible to propose the use of these compounds as dietary supplement for the prevention or as adjuvant to the only symptomatic treatments so far available for neurodegenerative diseases. |
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| Keywords: | antioxidants astaxanthin bacopa brain decline lycopene neuroprotection nutraceutical oxidative stress |
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