Molecular distribution of zinc in biliary and pancreatic secretions |
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Authors: | Bo Lönnerdal Barbara O Schneeman Carl L Keen Lucille S Hurley |
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Institution: | (1) Department of Nutrition, University of California, 95616 Davis, California |
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Abstract: | Rat bile and pancreatic fluid were examined for the presence of low molecular weight zinc complexes. Fluids were collected
separately by cannulation, and zinc distribution in collected samples was analyzed by gel filtration on Sephadex G-50. Most
of the zinc in bile was associated with low molecular weight zinc complexes; only a small amount of zinc was present in the
high molecular weight fraction. In contrast, pancreatic secretions did not contain low molecular weight zinc complexes, but
there were considerable amounts of zinc bound to high molecular weight compounds. The addition of zinc to bile resulted in
an increased amount of zinc in the low molecular weight fraction, while the addition of zinc to pancreatic fluid resulted
primarily in an increase in zinc bound to the high molecular weight components. Like pancreatic fluid, homogenates of pancreatic
tissue had no low molecular weight zinc complex. In rats whose bile and pancreatic fluid were removed and not returned into
the intestine, the amount of zinc bound to low molecular weight complexes in intestinal homogenates was reduced. This alteration
of the molecular distribution of zinc in intestinal homogenates by removal of bile and pancreatic fluid suggests the potential
importance of low molecular weight zinc complexes for zinc homeostasis. |
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Keywords: | Zinc in bile and pancreatic fluids low molecular weight zinc complexes zinc intestinal absorption bile zinc in fluids from pancreas zinc in fluids from zinc complexes in biliary and pancreatic secretions |
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