Time dependent study to evaluate the efficacy of zinc on hepatic marker enzymes and elemental profile in serum and liver of protein deficient rats |
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Authors: | Pardeep?Sidhu M L?Garg Email author" target="_blank">D K?DhawanEmail author |
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Institution: | (1) Department of Biophysics, Panjab University, Chandigarh UT, 160014, India |
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Abstract: | This study was designed to determine the time dependent protective effects of zinc sulfate on the serum and liver marker enzymes
along with elemental profile in protein deficient Sprauge Dawley (S.D.) female rats. Zinc sulfate in the dose of 227 mg/l
in drinking water was administrated to normal control as well as protein deficient rats for a total duration of 8 weeks. The
effects of different treatments were studied on enzymes like alkaline phosphatase (ALP), aspartate aminotransferases (AST)
and alanine aminotransferases (ALT) in rat serum at different time intervals of 1, 2, 4 and 8 weeks and in the rat liver at
the end of study. The status of different essential elements in liver was also studied. The serum ALP activity got significantly
depressed when estimated at the intervals of 4 and 8 weeks. Activity of serum ALT was significantly increased after 4 weeks
interval in protein deficient rats and the increasing trend continued upto 8 weeks of protein deficiency. On the other hand,
activity of AST showed a significant increase just after 2 weeks and activity continued to be increased up to 8 weeks. Moreover
activities of all the hepato marker enzymes showed a significant increase in liver of protein deficient rats. Interestingly,
supplementation of Zn to protein deficient rats helped in regulating the altered activities of ALP, AST and ALT both in serum
and liver. However, zinc treatment alone to normal rats did not indicate any significant change in the activities of all the
enzymes in liver as well serum except at the interval of 2 weeks where a marginal increase in the activity of AST was seen.
It has also been observed that concentrations of zinc, copper, iron and selenium were found to be decreased significantly
in protein deficient animals. However, the levels of these elements came back to within normal limits when zinc was administrated
to protein deficient rats.
Published online December 2004 |
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Keywords: | liver marker enzymes protein deficiency trace elements zinc |
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