Patch: platelet transfusion in cerebral haemorrhage: study protocol for a multicentre,randomised, controlled trial |
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| Authors: | Koen de Gans Rob J de Haan Charles B Majoie Maria M Koopman Anneke Brand Marcel G Dijkgraaf Marinus Vermeulen Yvo B Roos the PATCH Investigators |
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| Affiliation: | (1) Department of Neurology, Academic Medical Centre, H2-222, PO-box 22660, 1100 Amsterdam, DD, The Netherlands;(2) Clinical Research Unit, Academic Medical Centre, PO-box 22660, 1100 Amsterdam, DD, The Netherlands;(3) Department of Radiology, Academic Medical Centre, PO-box 22660, 1100 Amsterdam, DD, The Netherlands;(4) Sanquin Blood Bank, North West Region, PO-box 9137, 1006 Amsterdam, AC, The Netherlands;(5) South West Region, Department of Research and Development, Sanquin Blood Bank, Leiden, The Netherlands;(6) Department of Immune-Haematology and Transfusion Medicine, Leiden University Medical Centre, Leiden, The Netherlands;(7) Department of Clinical Epidemiology and Biostatistics, Academic Medical Centre, PO-box 22660, 1100 Amsterdam, DD, The Netherlands |
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| Abstract: | Background Patients suffering from intracerebral haemorrhage have a poor prognosis, especially if they are using antiplatelet therapy. Currently, no effective acute treatment option for intracerebral haemorrhage exists. Limiting the early growth of intracerebral haemorrhage volume which continues the first hours after admission seems a promising strategy. Because intracerebral haemorrhage patients who are on antiplatelet therapy have been shown to be particularly at risk of early haematoma growth, platelet transfusion may have a beneficial effect. |
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