Phospholipase and Proteinase Activities of Clinical Isolates of Candida from Immunocompromised Patients |
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| Authors: | C P Girish Kumar S Suresh Jothi Kumar Thangam Menon |
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| Institution: | (1) Department of Microbiology, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani,Chennai, 600 113, India |
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| Abstract: | Sixty-one isolates of Candida recovered from HIV seropositive and cancer patients were studied for elaboration of putative virulence determinants – phospholipase
(PL) and secreted aspartyl proteinase (Sap). Forty two (68.85%) isolates examined were PL producers and 51 (83.6%) were positive
for Sap. 57.37% (35/61) isolates produced both enzymes. Enzymatic activity was more pronounced in Candida albicans with 100% PL and 94.1% Sap activity. In contrast, non-C. albicans species demonstrated only 29.6% PL and 70.3% Sap activity, indicating interplay of other virulence determinants in these
yeasts in colonization and disease. |
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| Keywords: | Candida phospholipase secreted aspartyl proteinase virulence |
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