The Effects of Environmental Conditions on the In Vitro Activity of Selected Antimicrobial Agents Against Escherichia coli |
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| Authors: | Jaydeep Nanavaty Joel E. Mortensen Thomas R. Shryock |
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| Affiliation: | (1) College of Graduate Studies, Thomas Jefferson University, Philadelphia, PA, 19107 USA , US;(2) Department of Laboratory Medicine, St. Christopher's Hospital for Children, Erie Avenue at Front Street, Philadelphia, PA 19134-1095 USA , US;(3) Animal Science Discovery and Development Research, Elanco Animal Health, Greenfield, IN 46140, USA , US |
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| Abstract: | Various environmental conditions likely to be encountered at a nidus of infection were evaluated for their effect on selected
classes of antimicrobial agents. The minimum inhibitory concentration (MIC) of several aminoglycosides (apramycin, kanamycin,
gentamicin, tobramycin, amikacin), tetracycline, and chloramphenicol for five strains of E. coli were unchanged by temperature (35°–39.5°C), atmosphere (aerobic to anaerobic), pH > 7, NaCl concentration (up to 150 mM),
zinc concentration (up to 50 mM), and manganese (up to 10 mM). However, the aminoglycoside MICs were increased up to fivefold
at pH < 6.5. Magnesium and calcium ion concentrations >10 mM and ferric iron concentrations ≥10 mM increased aminoglycoside
MICs from 3.66- to 8-fold. Tetracycline MICs were increased 1.2- to 6.5-fold when the concentration of magnesium or calcium
was ≥10 mM. The results of this in vitro study might provide insight into the effects of local in vivo environmental conditions
on several classes of antimicrobial agents.
Received: 22 September 1997 / Accepted: 6 October 1997 |
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