首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins
Authors:Ryosuke Shirasaki  Geoffrey M Matthews  Sara Gandolfi  Ricardo de Matos Simoes  Dennis L Buckley  Joseline Raja Vora  Quinlan L Sievers  Johanna B Brüggenthies  Olga Dashevsky  Haley Poarch  Huihui Tang  Megan A Bariteau  Michal Sheffer  Yiguo Hu  Sondra L Downey-Kopyscinski  Paul J Hengeveld  Brian J Glassner  Eugen Dhimolea  Constantine S Mitsiades
Institution:1. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA;2. Harvard Medical School, Boston, MA, USA;3. Broad Institute of MIT and Harvard, Cambridge, MA, USA;4. Ludwig Center at Harvard, Boston, MA, USA;5. Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;6. Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA;7. Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard T.H. Chan School of Public Health, Boston, MA, USA;8. Department of Hematology, Amsterdam UMC, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, the Netherlands;9. Multiple Myeloma Research Foundation, Norwalk, CT, USA;10. University of Florida Health Cancer Center, Gainesville, FL, USA;11. Translational Genomics Research Institute, Phoenix, AZ, USA;12. Department of Hematology and Medical Oncology and the Winship Cancer Institute, Emory University, Atlanta, GA, USA
Abstract:
><ol class=
  • Download : Download high-res image (204KB)
  • Download : Download full-size image
  • Keywords:heterobifunctional proteolysis-targeting chimeric compounds  pharmacological degraders  resistance  CRISPR  CRBN  VHL  myeloma  PROTAC  E3 ligase  CRISPR activation
    本文献已被 ScienceDirect 等数据库收录!
    设为首页 | 免责声明 | 关于勤云 | 加入收藏

    Copyright©北京勤云科技发展有限公司  京ICP备09084417号