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Metabolic programs define dysfunctional immune responses in severe COVID-19 patients
Authors:Elizabeth A. Thompson  Katherine Cascino  Alvaro A. Ordonez  Weiqiang Zhou  Ajay Vaghasia  Anne Hamacher-Brady  Nathan R. Brady  Im-Hong Sun  Rulin Wang  Avi Z. Rosenberg  Michael Delannoy  Richard Rothman  Katherine Fenstermacher  Lauren Sauer  Kathyrn Shaw-Saliba  Evan M. Bloch  Andrew D. Redd  Aaron A.R. Tobian  Jonathan D. Powell
Affiliation:1. Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA;2. Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA;3. Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA;4. Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA;5. Department of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21287, USA;6. W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21287, USA;7. Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA;8. Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA;9. Department of Emergency Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA;10. Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, Baltimore, MD 21205, USA
Abstract:
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  • Keywords:COVID-19  SARS-CoV-2  immunology  metabolism  immunometabolism  T cells  MDSCs  apoptosis  mitochondria
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