CD14. |
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| Authors: | C Schütt |
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| Institution: | 1. School of Biological, Biomedical and Environmental Sciences, University of Hull, Hull, HU6 7RX, UK;2. Hull and York Medical School, University of Hull, Hull, HU6 7RX, UK;3. Department of Pathology, Hull and East Yorkshire Hospitals NHS Trust, Hull, HU3 2JZ, UK;4. Department of Hepatobiliary Surgery, Castle Hill Hospital, Cottingham, HU16 5JQ, UK;5. Queen’s Centre for Oncology and Haematology, Castle Hill Hospital, Cottingham, HU16 5JQ, UK |
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| Abstract: | The GPI-anchored 55 kDa glycoprotein CD14 is expressed on monocytes/macrophages and to a lesser extent on granulocytes. Engagement of CD14 by ligands like lipopolysaccharide, intact bacteria or apoptotic cells can result in either pro- or anti-inflammatory responses. Since the CD14 molecule does not have a membrane spanning domain it cannot transmit a signal into the cell. Some as yet unidentified accessory protein is thought to be involved. It will be important to clarify the signalling systems involved since they may provide a therapeutic target for sepsis intervention strategies. |
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