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TB or Not TB: how Mycobacterium tuberculosis may evade drug treatment
Authors:Friedberg Errol C  Fischhaber Paula L
Affiliation:Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.
Abstract:In this issue of Cell, a study by Valerie Mizrahi and her colleagues suggests that a putative error-prone DNA polymerase encoded by the dnaE2 gene of Mycobacterium tuberculosis may bypass certain types of DNA base damage, generating mutations. This may be an important mechanism for generating drug-resistant strains of M. tuberculosis.
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