Non-glucan Attached Proteins of Candida albicans Biofilm Formed on Various Surfaces |
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Authors: | Govindsamy Vediyappan W LaJean Chaffin |
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Institution: | (1) Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA |
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Abstract: | Non-glucan attached proteins of the cell surface and extracellular matrix of Candida albicans biofilms formed on two catheter surfaces and denture acrylic were examined. The SDS-PAGE protein profiles of these proteins
compared with that obtained from planktonic yeast cells and germ tubes were generally similar. This observation suggested
that this class of biofilm surface proteins is not composed of a unique set of extracellular proteins or that one or a few
proteins dominate the non-glucan attached proteins of biofilm. However, differences were observed in the proteins obtained
from biofilm formed on one catheter surface and two proteins, Grp2p and ORF19.822p, identified by mass spectrometry following
two-dimensional separation. These proteins have previously been associated with drug resistance and their presence or abundance
appeared to be influenced by the surface on which the biofilm was formed. |
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Keywords: | biofilm Candida albicans cell wall surface proteins |
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