Antagonism of fenfluramine-induced hyperthermia: a measure of central serotonin inhibition. |
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| Authors: | A Sulpizio P J Fowler E Macko |
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| Institution: | Department of Biological Research Smith Kline and French Laboratories Philadelphia, Pennsylvania 19101, USA |
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| Abstract: | Fenfluramine produced a rapid hyperthermic effect in rats housed in a warm (26–28 °C) environment. Drugs with known activity on serotonin-mediated pathways were the most effective antagonists of this hyperthermia. Among several anti-psychotic agents, clozapine was unique by virtue of its potent and specific antagonism of fenfluramine-induced hyperthermia. It is suggested that this serotonin blocking activity of clozapine may help to account for the lack of extrapyramidal symptoms (EPS) following administration of the drug to man. |
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