| 1型调节性T细胞的表型和功能 |
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| 引用本文： | 丁庆,周光炎.1型调节性T细胞的表型和功能[J].细胞生物学杂志,2006,28(5):681-684. |
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| 作者姓名： | 丁庆 周光炎 |
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| 作者单位： | 上海交通大学医学院 上海市免疫学研究所，上海市高校免疫学E研究院，上海交通大学医学院，上海市免疫学研究所，上海市高校免疫学E研究院，上海200025，上海200025 |
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| 摘 要： | 1型调节性T细胞(Tr1)在免疫耐受的诱导和维持过程中发挥重要作用。Tr1细胞通常在免疫耐受的环境中由外来抗原诱导产生,通过产生高水平的IL-10而发挥免疫抑制作用。而CD4 CD25 调节性T细胞(Tregs)可在胸腺中天然产生也可在外周被抗原诱导产生,通过细胞接触发挥抑制作用。现对Tr1细胞的表型、功能及其抑制作用机制等方面的研究进展进行综述。
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| 关 键 词： | 1型调节性T细胞 CD4 CD25 调节性T细胞 免疫耐受 |
| 收稿时间： | 2006-02-10 |
| 修稿时间： | 2006年2月10日 |
The Phenotypes and Functions of Type 1 Regulatory T cells |
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| Qing Ding,Kuang-Yen Chou.The Phenotypes and Functions of Type 1 Regulatory T cells[J].Chinese Journal of Cell Biology,2006,28(5):681-684. |
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| Authors: | Qing Ding Kuang-Yen Chou |
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| Institution: | Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine; E-Institute of Shanghai Universities, Immunology Division, Shanghai 200025, China |
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| Abstract: | CD4 type-1 regulatory T(Tr1) cells have an essential role in the induction and maintenance oftolerance to foreign and self-antigens,and they have been extensively characterized in mice and humans.Tr1 cellsproduce high levels of IL-10 and mediate IL-10-dependent suppression,whereas the effects of CD4 CD25 Tr cellsappear to be cell-contact-dependent.Tr1 cells arise in periphery upon encountering antigen in a tolerogenic environment.We have been interested in defining the characters of Tr1 cells,with the ultimate aim of designing therapeuticstrategies to harness their immunoregulatory effects.This review discussed the phenotypes and functions of Tr1cells,and the similarities and differences between Tr1 cells and CD4 CD25 Tr cells. |
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| Keywords: | type 1 regulatory T cells CD4 CD25 Tr cells immune tolerance |
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