Decreasedin vitro chemosensitivity of tumour cells in patients suffering from malignant diseases with a poor prognosis |
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| Authors: | Marián Hajdúch Vladimír Mihál Jozef Minařík Edgar Faber Mária Šafářová Evžen Weigl Petr Antálek |
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| Institution: | (1) Institute of Immunology, Faculty of Medicine, Palacký University, Hn votínská 3, Olomouc, Czech Republic;(2) Department of Paediatrics, Faculty of Medicine, Palacký University, Hnvotínská 3, Olomouc, Czech Republic;(3) Department of Oncology, Faculty of Medicine, Palacký University, Hnvotínská 3, Olomouc, Czech Republic;(4) Department of Haematology, Faculty of Medicine, Palacký University, Hnvotínská 3, Olomouc, Czech Republic |
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| Abstract: | The aim of the study was to assess the predictive value of MTTin vitro assay for evaluation of tumour cell resistance/sensitivity to cytotoxic drugs. We analyzed 105 samples of malignant cells of different origin. The study included patients with a diagnosis of acute and chronic lymphatic leukaemia, acute and chronic myeloid leukaemia, non-Hodgkin lymphoma, carcinoma of the lung, stomach and liver, rhabdomyosarcoma and breast carcinoma. The results demonstrate outstanding chemosensitivity in the majority of childhood acute lymphoblastic leukaemias, medium chemosensitivity of adult haematopoietic malignant diseases and chemoresistance of solid tumour cells. Our preliminary data suggest a good correlation betweenin vitro MTT assay and clinical curability of individual malignant diseases.Abbreviations ALL
acute lymphoid leukaemia
- AML
acute myeloid leukaemia
- CML
chronic myeloid leukaemia
- LCS50
50% leukaemic cell survival |
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| Keywords: | Acute lymphoid leukaemia acute myeloid leukaemia cytostatics drug resistance MTT-assay solid tumours |
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