Studies on DNA markers (D4S10 and D4S43/S127) genetically linked to Huntington's disease in Japanese families |
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| Authors: | Ichiro Kanazawa Ikuko Kondo Joh-E Ikeda Teruaki Ikeda Yuichior Shizu Mitsuo Yoshida Hirotaro Narabayashi Shigetoshi Kuroda Hisayuki Tsunoda Eiji Mizuta Yoko Okuno Kiyotaka Sugawara Miho Murata Mafuyu Takahashi James F. Gusella |
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| Affiliation: | (1) Department of Neurology, Institute of Clinical Medicine, University of Tsukuba, 305 Tsukuba-City, Japan;(2) Department of Ecology and Genetics, School of Health Sciences, Faculty of Medicine, University of Ryukyus, Okinawa, Japan;(3) Laboratory for Controls of Gene Expression, National Institute of Agrobiological Researches, Tsukuba-City, Japan;(4) Division of Psychiatry, Otaru Second Municipal Hospital, Otaru, Japan;(5) Division of Psychiatry, Ishigoh-oka Hospital, Chiba, Japan;(6) Department of Neurology, Jichi Medical School, Tochigi, Japan;(7) Neurological Clinic, Naka-meguro, Tokyo, Japan;(8) Department of Psychiatry, Okayama University, Okayama, Japan;(9) Division of Neurology, Tokyo Municipal Hospital for Neurological Disease, Fuchu, Tokyo, Japan;(10) Division of Neurology, National Utano Hospital, Kyoto, Japan;(11) Division of Psychiatry, Hara Hospital, Gumma, Japan;(12) Division of Pediatrics, Nishi-kohfu Hospital, Kohfu, Japan;(13) Department of Neurology, Tokyo Medical and Dental University, Tokyo, Japan;(14) Neurogenetics Laboratory Massachusetts General Hospital, 02129 Boston, MA, USA |
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| Abstract: | Summary This is the first full report on the genetic linkage between Japanese Huntington's disease and the DNA markers D4S10 and D4S43/S127. With use of the HindIII, BglI, and EcoRI polymorphisms detected at D4S10, and the combination of all these polymorphisms to give composite haplotypes, nine Japanese Huntington's disease families were found to be informative. Three recombinants for D4S10 were detected in these families, giving a maximum lod score of 1.662 at a  of 0.10. Similarly, when we used the MspI and PvuII polymorphisms detected by D4S43/S127, five families gave informative results. No recombinant was detected in these families, giving a maximum lod score of 3.348 at a of 0.00. These results clearly support the view that the Japanese Huntington's disease gene may be identical with the Western gene, in spite of the lower prevalence rate in Japan. |
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