Structural and functional analysis of rice genome |
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Authors: | Akhilesh K Tyagi Jitendra P Khurana Paramjit Khurana Saurabh Raghuvanshi Anupama Gaur Anita Kapur Vikrant Gupta Dibyendu Kumar V Ravi Shubha Vij Parul Khurana Sulabha Sharma |
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Institution: | (1) Department of Plant Molecular Biology, University of Delhi South Campus, Benito Juarez Road, 110 021 New Delhi, India |
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Abstract: | Rice is an excellent system for plant genomics as it represents a modest size genome of 430 Mb. It feeds more than half the
population of the world. Draft sequences of the rice genome, derived by whole-genome shotgun approach at relatively low coverage
(4-6 X), were published and the International Rice Genome Sequencing Project (IRGSP) declared high quality (> 10 X), genetically
anchored, phase 2 level sequence in 2002. In addition, phase 3 level finished sequence of chromosomes 1, 4 and 10 (out of
12 chromosomes of rice) has already been reported by scientists from IRGSP consortium. Various estimates of genes in rice
place the number at >50,000. Already, over 28,000 full-length cDNAs have been sequenced, most of which map to genetically
anchored genome sequence. Such information is very useful in revealing novel features of macroand micro-level synteny of rice
genome with other cereals. Microarray analysis is unraveling the identity of rice genes expressing in temporal and spatial
manner and should help target candidate genes useful for improving traits of agronomic importance. Simultaneously, functional
analysis of rice genome has been initiated by marker-based characterization of useful genes and employing functional knock-outs
created by mutation or gene tagging. Integration of this enormous information is expected to catalyze tremendous activity
on basic and applied aspects of rice genomics. |
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Keywords: | annotation comparative genomics functional genomics genetic mapping genome sequencing physical mapping rice |
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