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Conditional Maximum Likelihood Estimation Following a Group Sequential Test
Authors:Aiyi Liu  James F. Troendle  Kai F. Yu  Vivian W. Yuan
Abstract:
We consider estimation after a group sequential test. An estimator that is unbiased or has small bias may have substantial conditional bias (Troendle and Yu, 1999, Coburger and Wassmer, 2001). In this paper we derive the conditional maximum likelihood estimators of both the primary parameter and a secondary parameter, and investigate their properties within a conditional inference framework. The method applies to both the usual and adaptive group sequential test designs. (© 2004 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Keywords:Adaptive designs  Bias adjustment  Conditional bias  Interim analysis  Secondary endpoints
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