Increased oxidative stress in children with attention deficit hyperactivity disorder |
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| Authors: | Hatice Sezen Hasan Kandemir Emin Savik Sultan Basmacı Kandemir Fethiye Kilicaslan Hasan Bilinc |
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| Institution: | 1. Department of Clinical Biochemistry, Faculty of Medicine, Harran University, Sanliurfa, Turkeyhaticesezen27@mynet.com;3. Department of Child and Adolescent Psychiatry, Faculty of Medicine, Harran University, Sanliurfa, Turkey;4. Department of Clinical Biochemistry, Faculty of Medicine, Harran University, Sanliurfa, Turkey;5. Department of Psychiatry, Balikligol State Hospital, Sanliurfa, Turkey |
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| Abstract: | Objectives: The purpose of this study was to investigate oxidative stress in children with attention deficit hyperactivity disorder (ADHD).Methods: Total oxidant status (TOS), total antioxidant status (TAS), paraxonase-1 (PON-1) and arylesterase (ARE) activity were measured in 76 children (44 boys, 32 girls) diagnosed with ADHD according to the DSM-IV and 78 healthy children (46 boys, 32 girls).Results: Age and sex were similar between the groups (P?>?0.05). TOS and the oxidative stress index (OSI) were higher in the patient group than the control group (P?<?0.001). PON-1 (P?=?0.002), ARE (P?=?0.010) activity and TAS (P?<?0.001) were lower in the patient group than the control group.Discussion: We found decreased PON-1, ARE activity and TAS, and increased TOS and OSI in children with ADHD. Our study showed that there is significantly increased oxidative stress in children with ADHD. |
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| Keywords: | Attention deficit hyperactivity disorder Oxidative stress Paraxonase-1 Arylesterase |
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