| PKs的生物学功能 |
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| 引用本文： | 郑加翠[综述] 章慧平[审阅]. PKs的生物学功能[J]. 国外医学:分子生物学分册, 2010, 0(3): 279-282 |
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| 作者姓名： | 郑加翠[综述] 章慧平[审阅] |
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| 作者单位： | 华中科技大学同济医学院计划生育研究所,武汉市430030 |
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| 摘 要： | PKs是最近发现的多功能分泌蛋白,由PK1和PK2组成.在不同的系统中,它们通过两个高度同源G-蛋白偶联受体发挥各种生物学功能.它们与神经和血管的形成以及免疫应答的调节有关,并且对生殖系统的正常生理和促性腺激素释放激素系统的发育都有很大的影响.
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| 关 键 词： | 多功能分泌蛋白 内分泌腺来源的血管内皮生长因子 BV8蛋白 |
Biological Functions of the Prokineticins |
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| Affiliation: | ZHENG Jiacui, ZHANG Huiping( Research Institute of Family Planning, Tongji Medical College, Huazhong University of Science ＆ Technology, Wuhan, 430030, China) |
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| Abstract: | The prokineticins （PKs） are recently discovered muhifunctional secreted proteins, comprising of PK1 and PK2. PKs, through two highly homologous G protein-coupled receptors （ PKR1 and PKR2） , exert a variety of biological functions in different systems. They modulate neurogenesis, angiogenesis, as well as mmune response, and are associated with normal physiology of the reproductive system and development of the gonadotropin-releasing hormone system. |
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| Keywords: | muhifunctional secreted proteins endocrine gland-derivd vascular endothelial growth factor BV8 （Bombina variegata protein 8 kD） |
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