The c-myc locus is a common integration site in type B retrovirus-induced T-cell lymphomas |
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| Authors: | Rajan L Broussard D Lozano M Lee C G Kozak C A Dudley J P |
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| Affiliation: | Section of Molecular Genetics and Microbiology and Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas 78705, USA. |
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| Abstract: | ![]()
Type B leukemogenic virus (TBLV) induces rapidly appearing T-cell leukemias. TBLV insertions near the c-myc gene were detectable in 2 of 30 tumors tested, whereas 80% of the tumors showed c-myc overexpression. TBLV insertions on chromosome 15 (including a newly identified locus, Pad7) may cause c-myc overexpression by cis-acting effects at a distance. |
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