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GTAC enables parallel genotyping of multiple genomic loci with chromatin accessibility profiling in single cells
Institution:1. MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK;2. Oxford Centre for Haematology, NIHR Oxford Biomedical Research Centre, Oxford, UK;3. Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK;4. MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK;5. Flow Cytometry Facility, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK
Abstract:
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  • Keywords:single-cell technologies  chromatin accessibility  single-cell ATAC-seq  cancer evolution  tumor heterogeneity  leukemia stem cells  acute myeloid leukemia  clonal tracking  somatic mutation  epigenomics
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