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Advancing cell-based cancer immunotherapy through stem cell engineering
Affiliation:1. Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA;2. Mork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, CA 90089, USA;3. Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90089, USA;4. Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA;5. Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA;6. Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA
Abstract:
Keywords:stem cell  gene engineering  cancer immunotherapy  hematopoietic stem cell  embryonic stem cell  induced pluripotent stem cell  immune cell  T cell  natural killer cell  invariant natural killer T cell  mucosal-associated invariant T cell  gamma delta T cell  allogeneic off-the-shelf cell therapy  chimeric antigen receptor  T cell receptor  CRISPR-Cas9  lentivector  feeder-free culture  graft-versus-host disease  allorejection
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