Phytic acid exerts protective effects in cerebral ischemia-reperfusion injury by activating the anti-oxidative protein sestrin2 |
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| Authors: | Jing Liu Ying Li Chunli Mei Xianbin Ning Jinfeng Pang Lei Gu |
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| Institution: | 1. Neurology Department, Affiliated Hospital of Beihua University , Jilin, China;2. Rehabilitation Center, Beijing Xiaotangshan Hospital , Beijing, China;3. Neurology Department, Beihua University , Jilin, China;4. Neurosurgery Department, Affiliated Hospital of Beihua University , Jilin, China |
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| Abstract: | ABSTRACT Cerebral ischemia reperfusion (I/R) is a therapeutic strategy for ischemia; however, it usually causes injury by the aspect of inflammation and neuron apoptosis. This investigation aims to investigate the protective effects of phytic acid (IP6) for cerebral I/R injury in vitro. PC-12 cells under Oxygen and glucose deprivation/reperfusion (OGD/R) were performed to mimic cerebral I/R. IP6 was pretreated before PC-12 cells under OGD/R treatment. The data showed that IP6 activated the expression of sestrin2 in OGD/R injured PC-12 cells. IP6 inhibited OGD/R induced inflammation, oxidative stress, and apoptosis by activating sestrin2. Besides, p38 MAPK may mediate the effects of sestrin2 activated by IP6. Therefore, IP6 can be a potential drug to prevent neurological damage in cerebral I/R injury. |
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| Keywords: | Cerebral ischemia-reperfusion injury phytic acid oxidative stress sestrin2 |
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