Effects of dexamethasone on carnitine metabolism in liver and extrahepatic tissues |
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| Authors: | Timothy J French Anthony W Good T Norman Palmer Mary C Sugden |
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| Institution: | (1) Surgical Unit, The London Hospital, Whitechapel, E1 1BB London, UK;(2) Department of Biochemistry, Charing Cross and Westminster Medical School, Fulham Palace Road, Hammersmith, W6 8RF London, UK;(3) Department of Chemical Pathology, London Hospital Medical College, Turner Street, E1 2AD London, UK |
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| Abstract: | The in vivo effects of dexamethasone administration on liver and extrahepatic tissue carnitine concentrations were assessed in 48-h-starved rats. In heart and kidney, but not in liver, dexamethasone significantly increased total carnitine concentration. Acute (2.5 h) treatment with 2-tetradecylglycidate (TDG), a specific inhibitor of carnitine palmitoyl transferase 1, not only increased total hepatic carnitine concentrations, but also permitted an effect of dexamethasone (a further increase in hepatic carnitine concentration). The results are discussed in terms of acute (substrate-mediated) and chronic (hormonal) control of carnitine turnover. |
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