Change in permeability of liposomes caused by methylmercury and inorganic mercury |
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Authors: | S Nakada K Inoue S Nojima N Imura |
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Institution: | 1. School of Pharmaceutical Sciences, Kitasato University, 9-1, Shirokane 5 chome, Minato-ku, Tokyo, 108 Japan;2. Faculty of Pharmaceutical Sciences, University of Tokyo, 3-1, Hongo 7 chome, Bunkyo-ku, Tokyo, 113 Japan |
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Abstract: | The effects of two mercurial compounds, methylmercury and inorganic mercury, on lipids were examined by measuring permeability change of lipid bilayer, liposome. Both decrease in the cholesterol content and increase in the content of unsaturated fatty acid moieties in the lipid bilayers, augmented to susceptibility of the liposomes to the mercurial compounds. Inorganic mercury and methylmercury disrupted the lipid membrane to essentially the same extent. The influence on the permeability seems to be specific for mercury compounds. The significant increase in the permeability of some liposomal preparation noted even at the mercurial concentration of 10(-7) M strongly suggests that lipid in biomembrane could be one of the primary targets of these toxic substances. |
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Keywords: | DCP dicetyl phosphate SA stearylamine |
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