特比萘芬治疗顽固性手、足癣的临床疗效及安全性评价

目的评价特比萘芬治疗顽固性手、足癣的临床疗效及安全性。方法将120例患者随机分为实验组和对照组,实验组口服特比萘芬250mg,1次/d,联合外用特比萘芬乳膏,2次/d,连续3周;对照组患者仅外用特比萘芬乳膏2次/d,连续3周。停药2周后评价最终疗效和不良反应,停药4周后观察复发率。结果停药2周后,实验组患者的临床有效率为95%,真菌学清除率为95%,不良反应发生率为5%（主要为胃肠道反应）;对照组患者的临床有效率为40%,真菌学清除率为75%。停药4周后,实验组患者未见复发,对照组患者复发率为20%。结论口服特比萘芬联合外用特比萘芬乳膏治疗顽固性手、足癣是安全、有效的。

The safety and efficacy of terbinafine in the treatment of severe tinea manuum and tinea pedis

Objective To study the efficacy and safety of terbinafine in the treatment of tinea manuum and tinea pedis.Metheods One hundred and twenty cases of tinea manuum and tinea pedis were randomly divided into two groups.The study group was treated with oral terbinafine 250 mg daily,and terbinafine ointment 0.1% twice daily,continuously for 3 weeks.The control group was only treated with terbinafine ointment 0.1%,twice daily for continuously 3 weeks.After 2 weeks of stopping treatment,we observed clinical cure rates,and after 7 weeks,the recurernce rate.Results In the study group,the total clinical cure rate was 95% and the mycology clearance rate 95%.The incidence of adverse events was 5%.The majority were gastrointestinal disorders.In the control group,the total clinical cure rate was 40% and the total mycology clearance rate 75%,After 4 weeks of stopping treatment,the recurernce rate was zero in the study group and 20% in the control group.Conclusion Treating severe tinea manunm and tinea pedis with oral terbinafine and terbinafine ointment 0.1% is safe and effective.