DNA methylation restricts spontaneous multi-lineage differentiation of mesenchymal progenitor cells, but is stable during growth factor-induced terminal differentiation期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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DNA methylation restricts spontaneous multi-lineage differentiation of mesenchymal progenitor cells, but is stable during growth factor-induced terminal differentiation

Authors:	Marlinda Hupkes Eugene P van SomerenSjors HA Middelkamp Ester PiekEverardus J van Zoelen Koen J Dechering

Institution:	^a Department of Cell & Applied Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences (NCMLS), Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands ^b Department of Molecular Pharmacology, Merck Research Laboratories, PO Box 20, 5340 BH Oss, The Netherlands

Abstract:

Keywords:	5A(d)C 5-aza(deoxy)cytidine BMP bone morphogenetic protein ChIP chromatin immunoprecipitation Dnmt DNA methyltransferase ESC embryonic stem cell GM growth medium MeDIP methylated DNA immunoprecipitation MSC mesenchymal stem cell Pol-II RNA polymerase II
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