Synthesis and investigation of glycosylated mono- and diarylporphyrins for photodynamic therapy. |
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| Authors: | C Schell H K Hombrecher |
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| Institution: | 1. Univ. Grenoble Alpes, CERMAV, F-38000 Grenoble, France;2. CNRS, CERMAV, F-38000 Grenoble, France;3. Post-Graduate Program of Science and Materials Engineering, Universidade do Extremo Sul Catrinense UNESC, 88806-000 Criciúma, SC, Brazil;4. Departamento de Química, Universidade Federal de Santa Catarina, 88040-900 Florianópolis, SC, Brazil;5. Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, 09210-170 Santo André, SP, Brazil;1. Univ. Grenoble Alpes, DCM, 38000 Grenoble, France;2. CNRS, DCM, 38000 Grenoble, France;3. Institut Universitaire de France, 103 Boulevard Saint-Michel, 75005 Paris, France;1. Graduate School of Life Sciences, Toyo University, 1-1-1 Izumino, Itakura-machi, Ora-gun, Gumma 374-0193, Japan;2. Department of Life Sciences, Toyo University, 1-1-1 Izumino, Itakura-machi, Ora-gun, Gumma 374-0193, Japan;3. Bio-Nano Electronics Research Centre, Toyo University, 2100 Kujirai, Kawagoe, Saitama 350-8585, Japan |
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| Abstract: | The synthesis of a diaryl substituted porphyrin bearing a galactosyl and a cholesteryloxy substituent and of a galactosyl substituted monoaryl porphyrin is described. The spectroscopic and aggregation properties of both compounds were investigated. The galactosyl substituted monoaryl porphyrin (12) was efficiently incorporated into liposomes and lipoproteins whereas the diaryl porphyrin showed no interaction with these lipids. Furthermore the binding constants of compound 12 to HDL, LDL, VLDL, and PE and DMPC liposomes were estimated. |
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