Pancreatic polypeptide (PP)- and glucagon cells in the pancreatic islet of Xiphophorus helleri h. (Teleostei) |
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| Authors: | Dr. Catherine Klein Susan Van Noorden |
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| Affiliation: | (1) Laboratoire de Zoologie et d'Embryologie expérimentale, Université Louis Pasteur de Strasbourg, France;(2) Laboratoire de Physiologie Comparée des Régulations, CNRS, Strasbourg, France;(3) Department of Histochemistry, Royal Postgraduate Medical School, London, England;(4) Laboratoire de Zoologie et d'Embryologie expérimentale, 12 rue de l'Université, F-67000 Strasbourg, France |
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| Abstract: | Summary Correlative immunohistochemical and electron microscopical studies on the pancreatic islet of the teleost fish Xiphophorus helleri using antibodies to pancreatic polypeptide (PP) and glucagon show that separate cell types are responsible for the production of these peptides. The PP-cells correspond to the previously described  A2-cells with round granules , while the A2-cells with crystalline granules are the true glucagon cells. An earlier suggestion that there are two types of glucagon cells in teleost islets is therefore withdrawn.A portion of the results has been presented at Colloque annuel de la Société Française de Microscopie électronique, Lyon-Villeurbanne, 21–23 Mai 1979. Study supported in part by the Medical Research Council |
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| Keywords: | Pancreatic polypeptide (PP) Glucagon Pancreatic islet Xiphophorus helleri Immunohistochemistry Electron microscopy |
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