某些内科系统疾病患者血浆游离氨基酸的变化及意义

为了解某些内科系统疾病的血氨基酸代谢特点。测定１７０例９种内科系统急慢性疾病患者血浆游离氨基酸浓度,并分别与５８例健康人血浆氨基酸浓度作对比分析。９种疾病的血浆胱氨基酸浓度不同程度升高,以尿毒症病人最为显著,炎症性病人血浆苯丙、蛋、赖氨酸和苯丙／酪比值显著升高,丙、组、精、脯氨酸和支／芳比值显著降低;糖尿病和甲亢病人血浆总游离氨基酸、谷、丙、酪、赖和支链氨酸显著升高;糠尿病病人支／芳比值显著升高,表明不同疾病的血氨基酸浓度有特征性变化,炎症是导致血氨基酸代谢紊乱的重要因素

Changes in the Conten OF Free Amino Acids in Plasma of Patients Suffering from Some Internal Deseases

The content of free amino acids in plasma from 170 patients and from 58 healthy persons were determined. It was found that Plasma cysteine increased to defferent extent in patients suffering from 9 different categories of diseases and the peak values appeared in the plasma of patients suffering from uremia. The content of methioine and lysine and the ratio of Phe/Tyr increased significantly but the content of alanine, histidine, argnine and the ratio of BCAA/AAA decreased significantly in the plasma of patients with inflamation. The total amino acid, glutamic acid, alanine, tyrosine, lysine and BCAA increased markedly in the plasma of patients with diabetes and hyperthyroidium. The ratio of BCAA/AAA increased significantly in the plasma of patients with diabetes. In flammation may be the important factor resulting in metabolic disturbance of plasma amino acids.