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SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA
Affiliation:1. Biotechnology Center, Technische Universität Dresden, 01307 Dresden, Germany;2. Department of Microbiology and Cell Biology, Indian Institute of Science, 560012 Bengaluru, India;3. Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany;4. Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany;5. Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, 53127 Bonn, Germany;6. Center for Molecular and Cellular Bioengineering, Technische Universität Dresden, 01307 Dresden, Germany;7. Max Delbrück Center for Molecular Medicine, 13235 Berlin, Germany;8. Department of Biology, Universität Darmstadt, 64287 Darmstadt, Germany;9. Université de Lorraine, IMoPA UMR7365 CNRS-UL and UMS2008 IBSLor CNRS-Inserm-UL, 54505 Nancy, France;10. Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea;11. Charité Universitätsmedizin Berlin, 10117 Berlin, Germany;12. German Center for Cardiovascular Research (DZHK), Partner Site Berlin, 13235 Berlin, Germany;13. University Centre for Rare Diseases, Technische Universität Dresden, 01307 Dresden, Germany
Abstract:
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  • Keywords:SAMHD1  type I interferon  Aicardi-Goutières syndrome  condensate  phase separation  RNA  innate immunity  autoinflammation  dsRNA  stress granules
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