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Reactive metabolic byproducts contribute to antibiotic lethality under anaerobic conditions |
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| Affiliation: | 1. Institute for Medical Engineering & Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;2. Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;3. Harvard Center for Mass Spectrometry, Harvard University, Cambridge, MA 02138, USA;4. Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA |
| Abstract: |  |
| Keywords: | antibiotics mechanism of action metabolism reactive electrophilic species anaerobic antibiotic resistance antioxidants mass spectrometry macromolecular damage |
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