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Chromatin jets define the properties of cohesin-driven in vivo loop extrusion
Affiliation:1. MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London W12 0NN, UK;2. Sheng Yushou Center of Cell Biology and Immunology, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China;3. WLA Laboratories, Shanghai 201203, China;4. Department of Computing, Imperial College London, London SW7 2RH, UK;5. Department of Mathematics, Imperial College London, London SW7 2RH, UK;6. Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge CB3 0WA, UK;7. St John’s College, University of Cambridge, Cambridge CB2 1TP, UK;8. Department of Cell Biology, Erasmus University Medical Center, 3015 GD Rotterdam, the Netherlands;9. Sars International Centre for Marine Molecular Biology, University of Bergen, 5008 Bergen, Norway;10. Chair for AI in Healthcare and Medicine, Technical University of Munich, 81675 Munich, Germany
Abstract:
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  • Keywords:3D genome folding  cohesin  CTCF  loop extrusion
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