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Lactate is an epigenetic metabolite that drives survival in model systems of glioblastoma
Affiliation:1. Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA;2. Department of Neurological Surgery, Columbia University Medical Center, New York, NY 10032, USA;3. Department of Chemistry, University of Texas at Austin, Austin, TX 78712, USA;4. Proteomics and Metabolomics Core Facility, Weill Cornell Medicine, New York, NY 10021, USA;5. Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, 89081 Ulm, Germany;6. Department of Neurosurgery, Ulm University Medical Center, 89081 Ulm, Germany
Abstract:
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  • Keywords:lactate  glioblastoma  tumor metabolism  ATAC-seq  ChIP-seq  metabolic flux analysis
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