Relationship between fatty acid binding proteins,acetyl-CoA formation and fatty acid synthesis in developing human placenta |
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Authors: | Tanya Das Gaurisankar Sa Anup K Bandyopadhyay Manju Mukherjea |
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Institution: | (1) Department of Biochemistry, University College of Science, University of Calcutta, 35, Ballygunge Circular Road, 700 019 Calcutta, India |
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Abstract: | The relationship between fatty acid binding proteins, ATP citrate lyase activity and fatty acid synthesis in developing human
placenta has been studied. Fatty acid binding proteins reverse the inhibitory efect of palmitoyl-CoA and oleate on ATP citrate
lyase and fatty acid synthesis. In the absence of these inhibitors fatty acid binding proteins activate ATP citrate lyase
and stimulate 1-14 C] acetate incorporation into placental fatty acids indicating binding of endogenous inhibitors by these proteins. Thus these
proteins regulate the supply of acetyl-CoA as well as the synthesis of fatty acids from that substrates. As gestation proceeds
and more lipids are required by the developing placenta fatty acid binding protein content, activity of ATP citrate lyase
and rate of fatty acid synthesis increase indicating a cause and efect relationship between the demand of lipids and supply
of precursor fatty acids during human placental development. |
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Keywords: | ATP citrate lyase fatty acid binding proteins fatty acid synthesis placenta correlation |
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