Aortic Elasticity is Impaired in Patients with Endemic Fluorosis |
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Authors: | Ercan Varol Selahattin Akcay I Hakki Ersoy Mehmet Ozaydin Banu Kale Koroglu Simge Varol |
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Institution: | (1) Department of Cardiology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey;(2) Department of Endocrinology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey;(3) Department of Geology, Faculty of Engineering, Suleyman Demirel University, Isparta, Turkey;(4) Suleyman Demirel Univesitesi Tıp Fakultesi, Sevket Demirel Kalp Merkezi, Isparta, Turkey |
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Abstract: | Sixty-three patients with endemic fluorosis (36 males/27 females; mean age 33.9 ± 8.6 years) and 45 age-, sex-, and body mass
index-matched healthy controls (30 males/15 females; mean age 32.7 ± 8.8 years) were included in this study. Aortic stiffness
indices, aortic strain (AS), aortic distensibility (AD), and aortic strain index (ASI) were calculated from the aortic diameters
measured by echocardiography and blood pressure obtained by sphygmomanometry. The urine fluoride levels of fluorosis patients
were significantly higher than control subjects as expected (1.9 ± 0.1 mg/l vs. 0.4 ± 0.1 mg/l, respectively; P < 0.001). AS and AD were significantly lower in fluorosis patients than in the controls (for AS 5.3 ± 3.6 vs. 8.0 ± 3.4%;
P < 0.001 and for AD 0.2 ± 0.1 vs. 0.3 ± 0.1 cm2 dyn−1 10−3; P < 0.001, respectively). In contrast, signicantly higher ASI was observed in fluorosis patients than in the controls (3.4 ± 0.6
vs. 3.0 ± 0.4; P < 0.001, respectively). The results of our study demonstrate that elastic properties of ascending aorta are impaired in patients
with endemic fluorosis. |
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