Evidence for altered expression of the GTP-dependent regulatory proteins, Gs and Gi, in adipocytes from aged rats. |
| |
| Authors: | A Green and J L Johnson |
| |
| Institution: | Department of Internal Medicine, University of Texas Medical Branch, Galveston 77550. |
| |
| Abstract: | The alpha-subunits of Gi and Gs were quantified in adipocyte membranes from young (2-month) and older (18-month) rats by pertussis-toxin and cholera-toxin labelling respectively. Aging was associated with a 3-fold increase in Gi alpha-subunit, but only a 2-fold increase in one of the two Gs alpha-subunit species labelled. The findings may explain the altered sensitivity of adipocytes from aged rats to lipolytic and anti-lipolytic stimuli. |
| |
| Keywords: | |
|
|
