Functionality comparison of 3 classes of superdisintegrants in promoting aspirin tablet disintegration and dissolution |
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Authors: | Na Zhao Larry L Augsburger |
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Institution: | (1) University of Maryland School of Pharmacy, 21201 Baltimore, MD |
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Abstract: | The aims of this study are (1) to compare the disintegration efficiency, and (2) to develop a discriminating test model for
the 3 classes of superdisintegrants represented by Ac-Di-Sol, Primojel, and Polyplasdone XL10. Using a digital video camera
to examine the disintegration process of tablets containing the same wt/wt percentage concentration of the disintegrants,
Ac-Di-Sol was found to disintegrate tablets rapidly into apparently primary particles; Primojel also apparently disintegrated
tablets into primary particles but more slowly; Polyplasdone XL10 disintegrated tablets rapidly but into larger masses of
aggregated particles. The differences in the size distribution generated in the disintegrated tablets likely contribute to
the drug dissolution rate differences found for aspirin tablets with similar disintegration rates. The aspirin tablet matrix
is proposed as a model formulation for disintegrant efficiency comparison and performance consistency testing for quality
control purposes.
Published: December 12, 2005 |
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Keywords: | Superdisintegrants aspirin tablet disintegration dissolution test |
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