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Vaccination prepartum enhances the beneficial effects of melatonin on the immune response and reduces platelet responsiveness in sheep |
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| Authors: | Sergio Regodón Asunción Ramos María P Míguez Antonio Carrillo-Vico Juan A Rosado Isaac Jardín |
| Institution: | 1. Instituto de Investigaci??n en Recursos Cineg??ticos IREC (CSIC-UCLM-JCCM), Ronda de Toledo s/n, 13071, Ciudad Real, Spain 2. Center for Animal Disease Modeling and Surveillance (CADMS), Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA 3. CONICET/Facultad de Ciencias Veterinarias UNR, Boulevard Ovidio Lagos y Ruta 33, Casilda, Santa Fe, Argentina 4. Centro VISAVET, Universidad Complutense de Madrid, Avda. Puerta de Hierro S/N, 28040, Madrid, Spain 5. Subdirecci??n General de Sanidad de la Producci??n Primaria, Direcci??n General de Recursos Agr??colas y Ganaderos, Ministerio de Medio Ambiente y Medio Rural y Marino, C/ Alfonso XII, 62, 28071, Madrid, Spain 6. ??rea de Ganader??a, Direcci??n General de Medio Ambiente, Consejer??a de Medio Ambiente, Vivienda y Ordenaci??n del Territorio de la Comunidad de Madrid, C/ Ronda de Atocha 17, 28012, Madrid, Spain 7. Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, Avda. Puerta de Hierro S/N, 28040, Madrid, Spain |
| Abstract: | BackgroundEradication of bovine tuberculosis (bTB) through the application of test-and-cull programs is a declared goal of developed countries in which the disease is still endemic. Here, longitudinal data from more than 1,700 cattle herds tested during a 12?year-period in the eradication program in the region of Madrid, Spain, were analyzed to quantify the within-herd transmission coefficient (??) depending on the herd-type (beef/dairy/bullfighting). In addition, the probability to recover the officially bTB free (OTF) status in infected herds depending on the type of herd and the diagnostic strategy implemented was assessed using Cox proportional hazard models.ResultsOverall, dairy herds showed higher ?? (median 4.7) than beef or bullfighting herds (2.3 and 2.2 respectively). Introduction of interferon-gamma (IFN-??) as an ancillary test produced an apparent increase in the ?? coefficient regardless of production type, likely due to an increase in diagnostic sensitivity. Time to recover OTF status was also significantly lower in dairy herds, and length of bTB episodes was significantly reduced when the IFN-?? was implemented to manage the outbreak.ConclusionsOur results suggest that bTB spreads more rapidly in dairy herds compared to other herd types, a likely cause being management and demographic-related factors. However, outbreaks in dairy herds can be controlled more rapidly than in typically extensive herd types. Finally, IFN-?? proved its usefulness to rapidly eradicate bTB at a herd-level. |
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