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Single-molecule analysis reveals cooperative stimulation of Rad51 filament nucleation and growth by mediator proteins
Authors:Ondrej Belan  Consuelo Barroso  Artur Kaczmarczyk  Roopesh Anand  Stefania Federico  Nicola O’Reilly  Matthew D Newton  Erik Maeots  Radoslav I Enchev  Enrique Martinez-Perez  David S Rueda  Simon J Boulton
Institution:1. DSB Repair Metabolism Laboratory, The Francis Crick Institute, London NW1 1AT, UK;2. Meiosis group, MRC-London Institute of Medical Sciences, London W12 0NN, UK;3. Peptide Chemistry STP, The Francis Crick Institute, London NW1 1AT, UK;4. Department of Infectious Disease, Faculty of Medicine, Imperial College London, London W12 0NN, UK;5. Single Molecule Imaging Group, MRC-London Institute of Medical Sciences, London W12 0NN, UK;6. Visual Biochemistry Laboratory, The Francis Crick Institute, London NW1 1AT, UK
Abstract:
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  • Keywords:DNA repair  homologous recombination  single molecule approaches  Rad51 nucleoprotein filaments  BRCA2  Rad51 paralogs
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