Achiral Nucleotide Analogs: 5,5-Disubstituted Pyrimidines Related to Barbituric Acid |
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| Authors: | M. J. van Vliet J. Visscher A. W. Schwartz |
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| Affiliation: | Evolutionary Biology Research Group, Faculty of Science , University of Nijmegen , Toernooiveld 1, 6525 ED Nijmegen, The Netherlands |
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| Abstract: | ![]()
Abstract Achiral nucleotide analogs are of potential interest in origin of life studies. Four new 5,5-diphosphoethylpyrimidine analogs were prepared by condensation of urea or guanidine with a, a-di(2-[ethoxy-I-ethoxy]ethyl)malononitrile or a, a-di(2-[ethoxy-1-ethoxy]ethyl)ethyl cyanoacetate respectively, followed by removal of the protecting groups and bisphosphorylation. Oligomers of two potentially complementary analogs have been prepared. Interactions between these oligomers appear to be weak in aqueous solution. |
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