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Building Blocks for Synthesis of Oligoarabinonucleotides: Preparation of Arabinonucleoside H-Phosphonates from Protected Ribonucleosides |
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| Authors: | Eriks Rozners Erika Bizdena |
| Institution: | 1. Faculty of Chemical Technology, Riga Technical University , Azenes 14/24, Riga, LV, 1048, Latvia;2. Department of Organic Chemistry, Arrhenius Laboratory , Stockholm University , S-10691, Stockholm, Sweden;3. Faculty of Chemical Technology, Riga Technical University , Azenes 14/24, Riga, LV, 1048, Latvia |
| Abstract: | Abstract A straightforward and inexpensive synthesis of arabinonucleoside H-phosphonates has been developed. Arabinonucleosides were synthesised from protected ribonucleosides via 2′-keto derivatives. Reaction conditions have been optimised for compounds bearing labile N-protections. Further protecting group manipulation and phosphonylation gave the required H-phosphonate monomers. |
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